Dendrite arborization

Across TCGA patient cohorts, RNA activity of the Dendrite arborization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGF2BP1, RRAD, and FCER2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite arborization activity versus IGF2BP1 in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGF2BP1 →	+1.838	+0.600	<.001	<.001	3	7
OV	RRAD →	+1.116	+0.528	.007	.005	3	3
GBM	FCER2 →	+0.397	+0.472	.002	.002	2	4
GBM	AKT3 →	+0.318	+0.386	.005	.007	3	3
GBM	HABP4 →	+0.292	+0.376	.002	.009	3	3
GBM	MDGA2 →	+0.940	+0.610	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140059 vs IGF2BP1 — LSCC

Explore this scatter interactively →