Dendrite arborization

Across TCGA cell cohorts, RNA activity of the Dendrite arborization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H4C1, MIDN, and CD2BP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H4C1 grouped by Dendrite arborization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	H4C1 →	-0.527	-1.163	.004	.003	3	5
OVARY	MIDN →	-0.835	-1.039	.001	.001	3	4
BLOOD_Lymphoma	CD2BP2 →	-0.708	-1.471	.003	.001	3	4
STOMACH	PUS3 →	+0.706	+1.221	.008	.002	3	3
STOMACH	ANTXR2 →	-2.273	-1.007	<.001	.001	3	3
SKIN	ETV6 →	-0.494	-0.896	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H4C1 by Dendrite arborization activity — STOMACH

Explore this box plot interactively →