Dendrite arborization

Across TCGA cell cohorts, RNA activity of the Dendrite arborization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1A, WFDC8, and EFCAB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYO1A grouped by Dendrite arborization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYO1A →	+0.155	+0.229	<.001	.001	3	4
LUNG_NSCLC_LUAD	WFDC8 →	+0.139	+0.203	.001	.001	3	3
LUNG_NSCLC_LUAD	EFCAB3 →	-0.082	-0.190	.009	.001	3	3
SKIN	PECAM1 →	-0.173	-0.091	.004	.002	3	3
BLOOD_Leukemia	RPS6KA5 →	+0.191	+0.143	<.001	<.001	3	3
BLOOD_Leukemia	CALU →	-0.150	-0.223	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYO1A by Dendrite arborization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →