Mitochondrial gene expression

Across TCGA patient cohorts, RNA activity of the Mitochondrial gene expression pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2, DDX56, and PRCC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial gene expression activity versus RPRD2 in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPRD2 →	+0.319	+0.025	<.001	<.001	3	6
LSCC	DDX56 →	+0.301	+0.041	<.001	<.001	3	6
LUAD	PRCC →	+0.310	+0.031	<.001	<.001	3	6
LSCC	DARS2 →	+0.513	+0.045	<.001	<.001	3	6
LSCC	PAF1 →	+0.289	+0.057	<.001	<.001	3	6
GBM	RUNX1_S212 →	-0.514	-0.032	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140053 vs RPRD2 — OV

Explore this scatter interactively →