Mitochondrial gene expression

Across TCGA cell cohorts, RNA activity of the Mitochondrial gene expression pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPT1, MRPL38, and MRPS2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNPT1 grouped by Mitochondrial gene expression-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PNPT1 →	-0.578	-0.571	.005	<.001	2	14
URINARY_TRACT	MRPL38 →	-0.612	-0.577	.006	.007	2	14
BREAST	MRPS2 →	-0.278	-0.342	<.001	<.001	3	11
LUNG_NSCLC_LUAD	MRPS33 →	-0.482	-0.448	<.001	<.001	3	11
SKIN	MRPL58 →	-0.508	-0.550	.003	<.001	3	10
SOFT_TISSUE	MRPS15 →	-0.558	-0.549	.008	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNPT1 by Mitochondrial gene expression activity — STOMACH

Explore this box plot interactively →