Mitochondrial gene expression

Across TCGA cell cohorts, RNA activity of the Mitochondrial gene expression pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIT2, FAM114A1, and P3H1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial gene expression activity versus GIT2 in LARGE_INTESTINE (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GIT2 →	-0.664	-0.322	<.001	<.001	3	6
CNS	FAM114A1 →	-1.199	-0.421	<.001	<.001	3	6
LUNG_NSCLC_LUSC	P3H1 →	-2.248	-0.332	<.001	.008	3	6
OVARY	FTO →	-1.135	-0.307	<.001	<.001	3	6
LIVER	MAP1B →	-3.011	-0.413	.002	.004	3	6
CNS	PHF7 →	-0.795	-0.291	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140053 vs GIT2 — LARGE_INTESTINE

Explore this scatter interactively →