Mitochondrial gene expression

Across TCGA cell cohorts, RNA activity of the Mitochondrial gene expression pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRPL43, MRPL21, and MRPL27, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial gene expression activity versus MRPL43 in LIVER (Pearson r = 0.87).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MRPL43 →	+1.065	+0.709	<.001	<.001	3	20
LIVER	MRPL21 →	+0.970	+0.586	<.001	<.001	3	20
URINARY_TRACT	MRPL27 →	+0.909	+0.487	<.001	.004	3	20
LUNG_NSCLC_LUSC	DAP3 →	+1.582	+0.613	.002	.004	3	20
LUNG_NSCLC_LUSC	MRPS7 →	+1.229	+0.646	.002	.002	3	20
SOFT_TISSUE	MRPL38 →	+1.026	+0.511	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140053 vs MRPL43 — LIVER

Explore this scatter interactively →