Cellular response to oxidised low-density lipoprotein particle stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to oxidised low-density lipoprotein particle stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADAP2, RNASE6, and PRPF8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxidised low-density lipoprotein particle stimulus activity versus ADAP2 in GBM (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADAP2 →	+0.513	+0.089	<.001	<.001	3	8
GBM	RNASE6 →	+0.687	+0.118	<.001	<.001	3	8
BRCA	PRPF8 →	-0.256	-0.061	<.001	<.001	3	8
LSCC	UBE2O →	-0.271	-0.068	.001	.003	3	7
LSCC	MYBBP1A →	-0.327	-0.082	.001	<.001	3	7
LSCC	SF3B1 →	-0.267	-0.098	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140052 vs ADAP2 — GBM

Explore this scatter interactively →