Cellular response to oxidised low-density lipoprotein particle stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to oxidised low-density lipoprotein particle stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM28, PRR33, and HIF3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxidised low-density lipoprotein particle stimulus activity versus ADAM28 in UCEC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADAM28 →	+0.898	+0.580	.002	.002	3	5
LSCC	PRR33 →	+0.537	+0.551	<.001	<.001	3	5
PDAC	HIF3A →	-0.336	-0.422	.002	.005	3	4
LSCC	CMSS1 →	-0.627	-0.448	<.001	.006	3	4
LSCC	XPO1 →	-0.583	-0.519	<.001	<.001	3	4
LSCC	CYTH4 →	+0.476	+0.365	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140052 vs ADAM28 — UCEC

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