Cellular response to oxidised low-density lipoprotein particle stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to oxidised low-density lipoprotein particle stimulus pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1L2, IQCD, and MME, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HNRNPA1L2 grouped by Cellular response to oxidised low-density lipoprotein particle stimulus-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HNRNPA1L2 →	-0.587	-0.991	<.001	.001	3	4
KIDNEY	IQCD →	-1.302	-1.253	.004	.001	3	4
BREAST	MME →	-2.137	-0.775	.002	.004	3	4
BLOOD_Leukemia	ZNF14 →	-0.748	-0.645	.001	.007	3	3
CNS	RPL24 →	+0.477	+0.726	.005	.003	3	3
SKIN	NAXD →	-0.436	-1.111	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HNRNPA1L2 by Cellular response to oxidised low-density lipoprotein particle stimulus activity — KIDNEY

Explore this box plot interactively →