Cellular response to oxidised low-density lipoprotein particle stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to oxidised low-density lipoprotein particle stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPP38, FAM217A, and C17orf49, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxidised low-density lipoprotein particle stimulus activity versus RPP38 in BLOOD_Leukemia (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPP38 →	+0.554	+0.381	.002	.008	3	2
LUNG_NSCLC_LUAD	FAM217A →	-0.720	-1.899	.004	.006	2	2
BLOOD_Leukemia	C17orf49 →	+1.290	+0.404	.007	.003	3	1
BLOOD_Leukemia	H2AC14 →	+0.920	+0.381	.002	.008	3	1
BLOOD_Leukemia	TM9SF1 →	+0.349	+0.377	.006	.007	3	1
BLOOD_Leukemia	NPRL3 →	+1.230	+0.404	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140052 vs RPP38 — BLOOD_Leukemia

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