Exocytic process

Across TCGA cell cohorts, RNA activity of the Exocytic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILRUN, VAX2, and PPP1R18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocytic process activity versus ILRUN in CNS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ILRUN →	+0.482	+0.950	<.001	.003	3	4
BREAST	VAX2 →	-1.286	-0.798	.001	<.001	3	4
SOFT_TISSUE	PPP1R18 →	+0.782	+0.957	.006	.005	3	4
BREAST	ADAMTS13 →	-1.104	-0.770	.001	.002	3	4
OESOPHAGUS	PSME2 →	+1.145	+0.962	.009	.005	2	4
LUNG_NSCLC_LUSC	TP53TG5 →	+0.477	+1.578	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140029 vs ILRUN — CNS

Explore this scatter interactively →