Mitochondrial ADP transmembrane transport

Across TCGA patient cohorts, RNA activity of the Mitochondrial ADP transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC25A4, SF3A3, and SRSF4_S78, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial ADP transmembrane transport activity versus SLC25A4 in GBM (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC25A4 →	+0.607	+0.068	<.001	<.001	3	6
GBM	SF3A3 →	-0.301	-0.082	<.001	<.001	3	5
GBM	SRSF4_S78 →	-0.461	-0.049	<.001	<.001	3	5
GBM	VIRMA →	-0.228	-0.061	.002	.003	3	5
OV	TRIP10 →	-0.310	-0.051	.001	.007	2	6
CCRCC	MSRB2 →	+0.247	+0.054	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140021 vs SLC25A4 — GBM

Explore this scatter interactively →