Mitochondrial ADP transmembrane transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial ADP transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFPI, SMURF2, and KLF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TFPI grouped by Mitochondrial ADP transmembrane transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TFPI →	-2.478	-1.026	.006	.001	3	4
PANCREAS	SMURF2 →	-1.741	-1.235	<.001	.001	3	4
PANCREAS	KLF2 →	-2.146	-1.459	.001	.001	3	4
SOFT_TISSUE	UBQLN2 →	-0.950	-1.576	<.001	<.001	3	4
LUNG_SCLC	TANGO6 →	-0.816	-1.450	<.001	<.001	3	4
LUNG_SCLC	CAV1 →	-4.042	-1.272	.009	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TFPI by Mitochondrial ADP transmembrane transport activity — OVARY

Explore this box plot interactively →