Mitochondrial ADP transmembrane transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial ADP transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRSX, SLC25A6, and GTPBP6, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial ADP transmembrane transport activity versus DHRSX in OESOPHAGUS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DHRSX →	+1.151	+0.156	<.001	<.001	3	14
LUNG_NSCLC_LUSC	SLC25A6 →	+1.741	+0.116	<.001	<.001	2	13
LUNG_NSCLC_LUSC	GTPBP6 →	+1.184	+0.112	.005	<.001	2	12
BREAST	AKAP17A →	+1.371	+0.159	<.001	<.001	3	11
LUNG_SCLC	ZBED1 →	+1.135	+0.098	.001	<.001	3	8
OESOPHAGUS	PPP2R3B →	+0.950	+0.128	.009	.002	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140021 vs DHRSX — OESOPHAGUS

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