Mitochondrial ADP transmembrane transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial ADP transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A6, PDHA1, and ASMTL, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial ADP transmembrane transport activity versus SLC25A6 in LUNG_NSCLC_LUAD (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC25A6 →	+1.431	+0.206	<.001	<.001	3	11
PANCREAS	PDHA1 →	+1.224	+0.151	.003	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	ASMTL →	+1.403	+0.104	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	CD99 →	+2.015	+0.153	.001	<.001	3	8
URINARY_TRACT	SUV39H1 →	+1.102	+0.148	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	GTPBP6 →	+1.575	+0.118	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140021 vs SLC25A6 — LUNG_NSCLC_LUAD

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