Mitotic nuclear division

Across TCGA cell cohorts, RNA activity of the Mitotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTLC3, CLCN6, and MRPS15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTLC3 grouped by Mitotic nuclear division-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SPTLC3 →	+2.210	+0.281	<.001	.001	3	5
PANCREAS	CLCN6 →	-0.662	-0.151	<.001	.004	2	5
SOFT_TISSUE	MRPS15 →	-0.894	-0.189	<.001	.001	3	4
LARGE_INTESTINE	PSAT1 →	-1.294	-0.141	.002	.008	3	4
LUNG_NSCLC_LUAD	HNRNPLL →	-0.390	-0.105	.002	<.001	3	4
LUNG_NSCLC_LUAD	CTC1 →	-0.648	-0.086	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTLC3 by Mitotic nuclear division activity — KIDNEY

Explore this box plot interactively →