Mitotic nuclear division

Across TCGA cell cohorts, RNA activity of the Mitotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAVIN4, STMN1, and ZBTB12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear division activity versus CAVIN4 in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CAVIN4 →	+1.094	+0.147	<.001	<.001	3	7
BLOOD_Leukemia	STMN1 →	+1.169	+0.228	<.001	.009	3	7
BLOOD_Lymphoma	ZBTB12 →	+1.021	+0.185	.001	<.001	3	6
BLOOD_Lymphoma	UHRF1 →	+1.549	+0.200	<.001	<.001	3	5
BLOOD_Lymphoma	NCBP1 →	+0.643	+0.145	.007	.002	3	5
BLOOD_Leukemia	RECQL →	+1.009	+0.173	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140014 vs CAVIN4 — LUNG_SCLC

Explore this scatter interactively →