Mitotic nuclear division

Across TCGA cell cohorts, RNA activity of the Mitotic nuclear division pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIF22, UBE2S, and DNMT1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear division activity versus KIF22 in BONE (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KIF22 →	+1.209	+0.176	.002	.002	3	13
LUNG_SCLC	UBE2S →	+1.136	+0.142	<.001	<.001	3	11
LUNG_SCLC	DNMT1 →	+0.829	+0.196	<.001	<.001	3	11
PANCREAS	KIF4A →	+1.799	+0.246	<.001	<.001	3	10
PANCREAS	HNRNPM →	+0.461	+0.153	<.001	.003	2	11
LUNG_SCLC	SMC2 →	+0.900	+0.147	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140014 vs KIF22 — BONE

Explore this scatter interactively →