L-aspartate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the L-aspartate import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM, ACTR2, and GNB4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-aspartate import across plasma membrane activity versus VIM in COAD (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VIM →	+0.259	+0.048	<.001	<.001	3	6
COAD	ACTR2 →	+0.132	+0.089	.003	<.001	3	6
COAD	GNB4 →	+0.364	+0.050	.003	.008	3	6
LSCC	UBR5 →	-0.156	-0.063	<.001	.002	3	6
LSCC	TPR →	-0.214	-0.111	<.001	<.001	3	5
COAD	BCLAF1 →	-0.238	-0.063	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140009 vs VIM — COAD

Explore this scatter interactively →