L-aspartate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the L-aspartate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB20, CUBN, and ZNF454, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-aspartate import across plasma membrane activity versus ZBTB20 in LSCC (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZBTB20 →	-0.444	-0.587	<.001	<.001	3	5
HNSC	CUBN →	-0.687	-0.382	<.001	.003	3	5
LSCC	ZNF454 →	-0.468	-0.734	.003	<.001	3	5
LSCC	SLC1A5 →	+0.768	+0.952	<.001	<.001	3	4
LSCC	ZBTB20-AS1 →	-0.453	-0.739	<.001	<.001	3	4
CCRCC	SEPTIN4 →	-0.505	-0.742	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140009 vs ZBTB20 — LSCC

Explore this scatter interactively →