L-aspartate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the L-aspartate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERTAD3, RAB18, and POP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERTAD3 grouped by L-aspartate import across plasma membrane-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SERTAD3 →	-0.839	-0.732	<.001	.005	3	5
OESOPHAGUS	RAB18 →	-0.909	-0.872	.001	.004	2	5
UPPER_AERODIGESTIVE_TRACT	POP4 →	-0.711	-1.824	.008	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TMEM138 →	-0.476	-1.793	.005	<.001	3	4
SKIN	CHAMP1 →	-0.606	-0.761	.002	.002	3	4
LUNG_NSCLC_LUAD	ADAT1 →	-0.413	-0.816	.009	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERTAD3 by L-aspartate import across plasma membrane activity — PANCREAS

Explore this box plot interactively →