Sperm mitochondrial sheath assembly

Across TCGA patient cohorts, RNA activity of the Sperm mitochondrial sheath assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VDAC3, BDH1, and VIM_S22, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm mitochondrial sheath assembly activity versus VDAC3 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VDAC3 →	+0.585	+0.085	<.001	<.001	3	6
LSCC	BDH1 →	+0.762	+0.073	<.001	.001	3	5
BRCA	VIM_S22 →	-0.548	-0.057	<.001	<.001	3	5
BRCA	C1S →	-0.403	-0.058	<.001	<.001	3	5
BRCA	MRPL10 →	+0.331	+0.062	.002	.007	3	5
HNSC	SH2D4A →	+0.348	+0.093	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120317 vs VDAC3 — LSCC

Explore this scatter interactively →