Sperm mitochondrial sheath assembly

Across TCGA cell cohorts, RNA activity of the Sperm mitochondrial sheath assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS20, KIAA1958, and UHRF1BP1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGS20 grouped by Sperm mitochondrial sheath assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RGS20 →	+1.425	+1.204	.006	.003	3	4
STOMACH	KIAA1958 →	-0.943	-1.284	.008	.008	2	5
KIDNEY	UHRF1BP1L →	-0.798	-1.453	.001	<.001	3	3
KIDNEY	KRBOX4 →	-0.473	-1.303	.009	<.001	2	4
LUNG_NSCLC_LUSC	SDC4 →	+2.338	+1.467	.009	<.001	3	3
SKIN	RPAP1 →	+0.464	+0.877	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGS20 by Sperm mitochondrial sheath assembly activity — STOMACH

Explore this box plot interactively →