Sperm mitochondrial sheath assembly

Across TCGA cell cohorts, RNA activity of the Sperm mitochondrial sheath assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC198, ASIP, and PTGFR, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC198 grouped by Sperm mitochondrial sheath assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCDC198 →	+0.400	+0.238	<.001	<.001	3	1
BREAST	ASIP →	+0.290	+0.238	.004	<.001	3	1
BREAST	PTGFR →	+0.264	+0.238	.002	<.001	3	1
BREAST	UCK1 →	+0.339	+0.238	.002	<.001	3	1
BREAST	SIT1 →	+0.171	+0.238	<.001	<.001	3	1
BREAST	CREB5 →	+0.255	+0.238	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC198 by Sperm mitochondrial sheath assembly activity — BREAST

Explore this box plot interactively →