Sperm flagellum assembly

Across TCGA patient cohorts, RNA activity of the Sperm flagellum assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LZTFL1, IFT88, and IFT74, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm flagellum assembly activity versus LZTFL1 in BRCA (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LZTFL1 →	+0.459	+0.028	<.001	<.001	3	9
UCEC	IFT88 →	+0.424	+0.090	<.001	<.001	3	8
GBM	IFT74 →	+0.519	+0.094	<.001	<.001	3	7
GBM	BBS7 →	+0.404	+0.105	<.001	<.001	3	6
UCEC	RPGR_S961 →	+0.526	+0.085	<.001	<.001	3	6
BRCA	WDR19 →	+0.388	+0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120316 vs LZTFL1 — BRCA

Explore this scatter interactively →