Sperm flagellum assembly

Across TCGA cell cohorts, RNA activity of the Sperm flagellum assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUTM2A, FAM131A, and RBBP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm flagellum assembly activity versus NUTM2A in SOFT_TISSUE (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NUTM2A →	+0.542	+0.370	.005	.002	3	4
CNS	FAM131A →	+1.317	+0.272	.003	<.001	3	4
LUNG_NSCLC_LUSC	RBBP5 →	+0.614	+0.427	<.001	.002	3	3
LUNG_NSCLC_LUSC	ROMO1 →	-0.710	-0.409	.002	.001	3	3
LUNG_NSCLC_LUSC	ENC1 →	-2.553	-0.334	<.001	.002	3	3
LUNG_NSCLC_LUSC	FXYD5 →	-5.087	-0.334	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120316 vs NUTM2A — SOFT_TISSUE

Explore this scatter interactively →