Sperm flagellum assembly

Across TCGA cell cohorts, RNA activity of the Sperm flagellum assembly pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNHD1, NBEAL1, and KCNIP3, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm flagellum assembly activity versus DNHD1 in SOFT_TISSUE (Pearson r = 0.88).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNHD1 →	+2.672	+0.415	<.001	<.001	3	19
LARGE_INTESTINE	NBEAL1 →	-2.256	-0.438	.001	.001	3	14
KIDNEY	KCNIP3 →	-2.429	-0.360	<.001	.001	3	13
STOMACH	FGFRL1 →	-3.832	-0.484	<.001	<.001	3	12
OESOPHAGUS	PER3 →	-2.301	-0.508	<.001	.001	3	12
LUNG_SCLC	CLIP1 →	-0.678	-0.295	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120316 vs DNHD1 — SOFT_TISSUE

Explore this scatter interactively →