Regulation of pigmentation

Across TCGA patient cohorts, RNA activity of the Regulation of pigmentation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RASA3_S809, GRPEL1, and CORO2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pigmentation activity versus RASA3_S809 in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RASA3_S809 →	+0.713	+0.048	<.001	<.001	3	5
OV	GRPEL1 →	-0.420	-0.040	.003	.003	3	5
BRCA	CORO2B →	+0.474	+0.028	<.001	<.001	3	5
BRCA	ANK2_S846 →	+0.660	+0.033	.001	.002	3	5
BRCA	SEPTIN4 →	+0.274	+0.025	<.001	.001	3	4
BRCA	SEPTIN7 →	+0.222	+0.033	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120305 vs RASA3_S809 — OV

Explore this scatter interactively →