Regulation of pigmentation

Across TCGA patient cohorts, RNA activity of the Regulation of pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNRF3, ACTR6, and OXR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pigmentation activity versus ZNRF3 in CCRCC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNRF3 →	-0.501	-0.521	.006	.007	3	4
LSCC	ACTR6 →	-0.505	-0.121	.009	.003	3	4
GBM	OXR1 →	-0.416	-0.623	<.001	.002	3	4
BRCA	SCYL2 →	-0.389	-0.408	.002	.003	3	4
LSCC	CELF2-AS1 →	+0.548	+0.122	<.001	.009	3	3
LSCC	SUDS3 →	-0.298	-0.145	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120305 vs ZNRF3 — CCRCC

Explore this scatter interactively →