Regulation of pigmentation

Across TCGA cell cohorts, RNA activity of the Regulation of pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAH1, PDPR, and DYNC1LI2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAH1 grouped by Regulation of pigmentation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNAH1 →	-1.350	-1.531	<.001	<.001	3	4
CNS	PDPR →	-0.989	-0.916	.001	.007	3	4
OESOPHAGUS	DYNC1LI2 →	-0.976	-1.965	.006	<.001	3	4
STOMACH	RPS3A →	+0.714	+1.510	.008	<.001	3	4
PANCREAS	ARG2 →	+2.704	+2.172	.004	<.001	2	4
BONE	JCHAIN →	-0.975	-1.920	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAH1 by Regulation of pigmentation activity — SOFT_TISSUE

Explore this box plot interactively →