Regulation of pigmentation

Across TCGA cell cohorts, RNA activity of the Regulation of pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AATF, RNF11, and BLOC1S1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pigmentation activity versus AATF in CNS (Pearson r = -0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	AATF →	-1.415	-0.621	.006	.001	3	2
BLOOD_Leukemia	RNF11 →	-0.803	-0.511	.004	.008	3	2
BLOOD_Leukemia	BLOC1S1 →	+0.823	+0.376	<.001	.006	3	2
BLOOD_Leukemia	SPRED1 →	-1.477	-0.376	.005	.001	3	2
BLOOD_Leukemia	ZMYM1 →	-0.646	-0.379	.009	<.001	3	2
LUNG_SCLC	PTOV1 →	-0.952	-0.229	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120305 vs AATF — CNS

Explore this scatter interactively →