Regulation of heterochromatin organization

Across TCGA patient cohorts, RNA activity of the Regulation of heterochromatin organization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRBP1_T275, ARID1B, and SMARCC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heterochromatin organization activity versus RRBP1_T275 in CCRCC (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RRBP1_T275 →	-0.636	-0.031	.003	.001	3	7
GBM	ARID1B →	+0.167	+0.047	<.001	<.001	3	7
GBM	SMARCC2 →	+0.379	+0.069	<.001	<.001	3	6
LSCC	S100A9 →	-1.090	-0.043	<.001	.006	3	6
HNSC	RIN1 →	-0.651	-0.087	<.001	<.001	3	6
GBM	ING4 →	+0.388	+0.053	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120261 vs RRBP1_T275 — CCRCC

Explore this scatter interactively →