Regulation of heterochromatin organization

Across TCGA cell cohorts, RNA activity of the Regulation of heterochromatin organization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP7B, SPSB3, and SHROOM3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP7B grouped by Regulation of heterochromatin organization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATP7B →	-0.799	-0.266	.003	<.001	3	4
LUNG_NSCLC_LUSC	SPSB3 →	+1.084	+0.398	.002	<.001	3	4
OVARY	SHROOM3 →	+2.208	+0.366	<.001	.002	3	4
LARGE_INTESTINE	GLIPR2 →	-1.414	-0.182	.005	.007	3	4
URINARY_TRACT	EIF5A2 →	-2.645	-0.169	.005	.002	3	4
BLOOD_Myeloma	IFFO2 →	+2.128	+0.376	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP7B by Regulation of heterochromatin organization activity — SKIN

Explore this box plot interactively →