Regulation of heterochromatin organization

Across TCGA cell cohorts, RNA activity of the Regulation of heterochromatin organization pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF9, SLC4A8, and SEMA4D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heterochromatin organization activity versus KIF9 in KIDNEY (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KIF9 →	-0.783	-0.786	.003	.007	3	3
UPPER_AERODIGESTIVE_TRACT	SLC4A8 →	-0.366	-0.317	.005	.002	3	3
BREAST	SEMA4D →	+1.066	+0.330	.001	.009	3	3
BONE	EFL1 →	+0.740	+0.284	.008	.007	3	3
SKIN	C15orf39 →	+0.894	+0.575	<.001	.007	3	3
BONE	CCDC142 →	+0.719	+0.234	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120261 vs KIF9 — KIDNEY

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