Olefinic compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Olefinic compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TDP2, GFUS, and COA6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olefinic compound biosynthetic process activity versus TDP2 in OESOPHAGUS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TDP2 →	+1.065	+0.365	.004	.006	2	5
CNS	GFUS →	+0.747	+0.286	.001	.001	3	3
LUNG_NSCLC_LUSC	COA6 →	+1.236	+0.586	.004	.003	1	5
LUNG_NSCLC_LUAD	HGD →	+2.827	+0.454	.008	.001	3	3
LUNG_NSCLC_LUAD	PLCH1 →	+1.185	+0.528	.004	<.001	3	3
LUNG_NSCLC_LUAD	SEMA7A →	-1.859	-0.424	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120255 vs TDP2 — OESOPHAGUS

Explore this scatter interactively →