Olefinic compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Olefinic compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSD3B1, AKR1D1, and PGD, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olefinic compound biosynthetic process activity versus HSD3B1 in LUNG_NSCLC_LUSC (Pearson r = 0.89).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HSD3B1 →	+2.955	+0.583	.005	<.001	2	11
LUNG_NSCLC_LUAD	AKR1D1 →	+4.312	+0.494	<.001	<.001	3	8
LUNG_NSCLC_LUSC	PGD →	+2.154	+0.583	.001	<.001	2	9
OESOPHAGUS	AKR1C3 →	+3.480	+0.432	.002	.005	3	8
LUNG_NSCLC_LUAD	GPI →	+1.272	+0.350	<.001	.006	3	6
LUNG_NSCLC_LUAD	SRP68 →	+0.660	+0.328	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120255 vs HSD3B1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →