Olefinic compound metabolic process

Across TCGA patient cohorts, RNA activity of the Olefinic compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, MAOA, and ZC3H13_T362, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olefinic compound metabolic process activity versus AKR1C3 in LUAD (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKR1C3 →	+1.202	+0.051	<.001	<.001	3	8
BRCA	MAOA →	+0.663	+0.018	.003	.001	3	8
UCEC	ZC3H13_T362 →	-0.166	-0.032	.005	.007	3	8
OV	SF3B1 →	-0.290	-0.022	<.001	.001	3	7
GBM	SMCHD1 →	-0.326	-0.028	<.001	<.001	3	7
GBM	SNRNP70 →	-0.204	-0.021	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120254 vs AKR1C3 — LUAD

Explore this scatter interactively →