Olefinic compound metabolic process

Across TCGA cell cohorts, RNA activity of the Olefinic compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSE1L, KPNA2, and PRRG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSE1L grouped by Olefinic compound metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSE1L →	+0.864	+1.100	.008	<.001	3	5
BLOOD_Lymphoma	KPNA2 →	+1.200	+1.748	.002	<.001	3	5
BREAST	PRRG1 →	+1.190	+0.693	<.001	.003	3	5
STOMACH	BMS1 →	+0.908	+1.354	.009	<.001	3	4
STOMACH	IRF2BP2 →	-1.168	-1.482	.005	<.001	2	5
SOFT_TISSUE	SLC37A2 →	+0.975	+1.243	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSE1L by Olefinic compound metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →