Olefinic compound metabolic process

Across TCGA cell cohorts, RNA activity of the Olefinic compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADCY7, JUN, and ITGA6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olefinic compound metabolic process activity versus ADCY7 in STOMACH (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADCY7 →	-2.378	-0.292	.006	.001	3	5
BLOOD_Leukemia	JUN →	-1.127	-0.131	.002	<.001	3	5
BLOOD_Lymphoma	ITGA6 →	-1.985	-0.260	<.001	.002	3	4
LIVER	DHRS7B →	+0.894	+0.301	.001	.004	3	4
LIVER	RFTN1 →	-2.568	-0.279	.002	.009	3	4
LIVER	ISL2 →	+1.337	+0.364	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120254 vs ADCY7 — STOMACH

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