Hydrocarbon metabolic process

Across TCGA patient cohorts, RNA activity of the Hydrocarbon metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP32_S682, INPP1, and KIF21A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrocarbon metabolic process activity versus ARHGAP32_S682 in HNSC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP32_S682 →	+0.606	+0.695	<.001	<.001	3	5
GBM	INPP1 →	+0.330	+0.553	<.001	<.001	3	5
GBM	KIF21A →	+0.472	+0.779	<.001	<.001	3	5
UCEC	HGD →	+0.625	+0.655	.001	<.001	3	5
BRCA	CAMSAP3_S334 →	+0.492	+0.494	.002	.008	2	5
BRCA	MAP1B_S1965 →	-0.363	-0.358	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120252 vs ARHGAP32_S682 — HNSC

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