Hydrocarbon metabolic process

Across TCGA cell cohorts, RNA activity of the Hydrocarbon metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL20, LSM11, and CNOT11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL20 grouped by Hydrocarbon metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KLHL20 →	-0.978	-1.501	.001	.002	3	4
CNS	LSM11 →	-0.506	-0.955	<.001	.003	3	4
OVARY	CNOT11 →	-0.418	-1.116	.003	.003	3	4
BREAST	WDR73 →	-0.521	-0.886	.008	.001	3	4
STOMACH	DAB2IP →	-1.546	-1.204	.009	.006	3	4
STOMACH	FUT7 →	-0.150	-1.043	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL20 by Hydrocarbon metabolic process activity — OESOPHAGUS

Explore this box plot interactively →