Hydrocarbon metabolic process

Across TCGA cell cohorts, RNA activity of the Hydrocarbon metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDPD2, GPX7, and RTN4IP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDPD2 grouped by Hydrocarbon metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GDPD2 →	+0.199	+1.074	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	GPX7 →	+0.182	+1.789	.006	<.001	3	4
BLOOD_Lymphoma	RTN4IP1 →	+0.217	+0.238	.007	.001	3	4
BREAST	SAE1 →	+0.292	+0.684	.001	.005	3	4
OESOPHAGUS	ZSCAN9 →	-0.227	-1.743	<.001	<.001	3	3
STOMACH	FBXO8 →	-0.258	-1.383	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDPD2 by Hydrocarbon metabolic process activity — STOMACH

Explore this box plot interactively →