Tight junction organization

Across TCGA patient cohorts, RNA activity of the Tight junction organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP97, SIX4, and CASD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tight junction organization activity versus CEP97 in COAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP97 →	-0.465	-0.801	<.001	.003	3	3
HNSC	SIX4 →	-0.983	-0.753	.001	.003	3	2
HNSC	CASD1 →	-1.002	-0.937	.001	.004	3	2
HNSC	INAVA →	+1.030	+0.695	<.001	.002	3	2
HNSC	S100A14 →	+1.660	+1.247	.005	<.001	3	2
BRCA	PMEPA1 →	+0.851	+0.525	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120193 vs CEP97 — COAD

Explore this scatter interactively →