Tight junction organization

Across TCGA cell cohorts, RNA activity of the Tight junction organization pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTF2, ACTG1, and CLIC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTF2 grouped by Tight junction organization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TTF2 →	-0.194	-0.691	<.001	.008	2	7
OVARY	ACTG1 →	-0.334	-0.779	.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	CLIC3 →	-0.197	-0.181	.002	.002	3	4
CNS	ADGRD2 →	-0.426	-0.933	<.001	.001	3	4
OESOPHAGUS	DDX19B →	-0.396	-0.290	<.001	.009	3	4
OVARY	CCR7 →	-0.332	-1.014	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTF2 by Tight junction organization activity — CNS

Explore this box plot interactively →