Tight junction organization

Across TCGA cell cohorts, RNA activity of the Tight junction organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAN2, SCCPDH, and TUBA1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tight junction organization activity versus PAN2 in BLOOD_Myeloma (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PAN2 →	-0.561	-0.215	.001	<.001	3	4
BLOOD_Myeloma	SCCPDH →	+2.734	+0.210	.002	.006	3	4
BONE	TUBA1B →	+0.625	+0.184	.001	.002	3	4
SOFT_TISSUE	RXYLT1 →	+0.712	+0.297	.003	<.001	3	4
SOFT_TISSUE	PODXL →	+3.120	+0.219	.004	.006	3	4
BLOOD_Myeloma	CLTRN →	-0.475	-0.282	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120193 vs PAN2 — BLOOD_Myeloma

Explore this scatter interactively →