Regulation of bile acid secretion

Across TCGA patient cohorts, RNA activity of the Regulation of bile acid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES1, CORO1C, and ME1_S336, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of bile acid secretion activity versus CES1 in LSCC (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CES1 →	+1.876	+0.203	<.001	<.001	3	7
BRCA	CORO1C →	+0.470	+0.121	<.001	<.001	3	5
LSCC	ME1_S336 →	+0.962	+0.155	<.001	<.001	3	5
BRCA	DMXL1_S1285 →	-0.630	-0.072	.001	.006	3	4
BRCA	MYLK_S1760 →	+0.515	+0.086	.002	<.001	3	4
LUAD	CYBRD1_T285 →	+0.368	+0.101	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120188 vs CES1 — LSCC

Explore this scatter interactively →