Regulation of bile acid secretion

Across TCGA cell cohorts, RNA activity of the Regulation of bile acid secretion pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMC2, ZNF516, and LRRC3C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EMC2 grouped by Regulation of bile acid secretion-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EMC2 →	+0.435	+1.994	.005	<.001	3	4
BLOOD_Leukemia	ZNF516 →	-1.572	-0.852	.001	.007	3	4
STOMACH	LRRC3C →	+0.058	+1.364	.007	.003	3	3
STOMACH	STOML1 →	+0.780	+1.084	<.001	.002	3	3
LARGE_INTESTINE	VPS37C →	+0.481	+1.131	<.001	<.001	2	4
KIDNEY	AP2A2 →	+0.765	+1.177	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EMC2 by Regulation of bile acid secretion activity — URINARY_TRACT

Explore this box plot interactively →