Negative regulation of protein localization to chromatin

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to chromatin pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIRT6_T294, DPP9, and TLR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to chromatin activity versus SIRT6_T294 in LUAD (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SIRT6_T294 →	+0.339	+0.056	<.001	<.001	3	5
LSCC	DPP9 →	+0.145	+0.054	<.001	<.001	3	5
COAD	TLR2 →	+0.629	+0.063	.001	<.001	3	5
HNSC	RIF1_S1688 →	-0.760	-0.091	.001	.001	3	4
OV	SH3GL1 →	+0.292	+0.061	<.001	.001	2	5
LSCC	SIRT6 →	+0.227	+0.058	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120186 vs SIRT6_T294 — LUAD

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