Negative regulation of protein localization to chromatin

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to chromatin pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR1, PJA2, and NSUN5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to chromatin activity versus ACVR1 in OV (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACVR1 →	-0.737	-0.338	<.001	.003	3	4
HNSC	PJA2 →	-0.645	-0.262	.007	.009	3	4
BRCA	NSUN5 →	+0.446	+0.518	.003	.006	3	4
LUAD	GAB1 →	-0.412	-0.424	.001	.001	3	4
OV	TNS1 →	-1.211	-0.350	.001	.001	3	4
OV	ITGB5 →	-0.944	-0.297	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120186 vs ACVR1 — OV

Explore this scatter interactively →